Sequencing Error-reduction through Consensus Calling Reads from the same Source Molecule

August 4, 2017Bioinformatics No Comments

Dramatic sequencing error-reduction can be achieved through calling consensus reads that observe the same source molecule.   This is extremely important for low-frequency variant detection in somatic samples, as well as genotyping STRs (short-tandem repeats) where high rates of “stutter” can be overcome.  I will review the method behind calling consensus reads. There are two … Read More